Neuroleptanalgesia

• Major tranquilliser

  • Chlorpromazine, Droperidol

• Opiate

  • Fentanyl, Morphine, Omnopon

• Delay (1959)

  • Drug induced behavioural syndrome
    • Inhibition of purposeful movement
    • Inhibition of learned behaviour
    • Catalepsis
    • Inhibition of vomiting

• Other side effects
  • Alpha-adrenergic blockade
  • Hypothermia
  • Extra-pyramidal effects
  • Anticholinergic effects

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