Thiopentone

Pharmacokinetics

Distribution
5 mg/Kg over 15 secs mixes with 1200 mL blood
35 mg/mL of free drug
redistributed over 3 mins
leaves VRG of tissues
level falls to 20% of original (7 mg /mL)
muscle peaks at 20 mins
fat peaks at 45 mins
Vd 1.2 - 2 L/Kg
t 1/2 alpha (distribution) is 2.5 mins
t 1/2 beta (redistribution) is 45 mins

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Friday, 19 September 2008 06:33:56