Thiopentone elimination

Clearance adults 3 mL.Kg-1.min-1 (mL/Kg/min) children 6 mL.Kg-1.min-1 (mL/Kg/min) T 1/2 beta 8 - 10 hrs ( 4-6 in children) rate controlled by return from peripheral compartment Vdss 1- 2 L/Kg

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