Ketamine Pharmacokinetics
 | Dose
 | IVI 2 mg/Kg (can be given orally or IMI)
| maintenance infusion:
 | 2 - 4 mg.Kg-1.hour-1 (anaesthesia)
| 1 - 2 mg.Kg-1.hour-1 (analgesia)
| | | | |
| Elimination
|
| by metabolism
| t 1/2 b 2-3 hours
| depends on liver blood flow
| Vdss 3-8 l/Kg
| Clearance 18 ml.Kg-1.min-1
| | | | | Norketamine is pharmacologically active
| offset by redistribution | | |
| |
|
